diff --git a/configure.ac b/configure.ac
index bd46b33e85d..fc71b74c961 100644
--- a/configure.ac
+++ b/configure.ac
@@ -45,6 +45,7 @@ LT_PREREQ(2.2)
 LT_INIT([disable-static])
 
 AS_IF([test "x$enable_static" = "xyes"], [AC_MSG_ERROR([--enable-static is not supported by systemd])])
+AS_IF([test "x$enable_largefile" = "xno"], [AC_MSG_ERROR([--disable-largefile is not supported by systemd])])
 
 # i18n stuff for the PolicyKit policy files
 IT_PROG_INTLTOOL([0.40.0])