diff --git a/runtime/doc/news.txt b/runtime/doc/news.txt
index 29fcb5abbf..00a620955e 100644
--- a/runtime/doc/news.txt
+++ b/runtime/doc/news.txt
@@ -96,6 +96,8 @@ API
 • |nvim_clear_autocmds()| no longer treats an empty array event as nil.
 • |vim.o|, |vim.opt|, and |nvim_set_option_value()| expand `~` and environment
   variables (|expand-env|).
+• Security: The |TUI| (also with |--remote-ui|) rejects server-to-client API
+  calls. Only UI events are allowed.
 
 DIAGNOSTICS
 
diff --git a/src/nvim/msgpack_rpc/channel.c b/src/nvim/msgpack_rpc/channel.c
index fc08084eeb..c9df280746 100644
--- a/src/nvim/msgpack_rpc/channel.c
+++ b/src/nvim/msgpack_rpc/channel.c
@@ -314,6 +314,15 @@ static void handle_request(Channel *channel, Unpacker *p, Array args)
 {
   assert(p->type == kMessageTypeRequest || p->type == kMessageTypeNotification);
 
+  // SECURITY: only allow UI events, disallow server-to-client API calls. Else a malicious (remote)
+  // server could run arbitrary code in the local UI process.
+  if (p->handler.fn && p->handler.fn != handle_nvim_error_event
+      && ui_client_channel_id && channel->id == ui_client_channel_id) {
+    api_set_error(&p->unpack_error, kErrorTypeException, "UI client does not accept API calls: %s",
+                  p->handler.name);
+    p->handler.fn = NULL;
+  }
+
   if (!p->handler.fn) {
     send_error(channel, p->handler, p->type, p->request_id, p->unpack_error.msg);
     api_clear_error(&p->unpack_error);
diff --git a/test/functional/terminal/tui_spec.lua b/test/functional/terminal/tui_spec.lua
index a8c5e5efa7..3374e95bb3 100644
--- a/test/functional/terminal/tui_spec.lua
+++ b/test/functional/terminal/tui_spec.lua
@@ -3466,6 +3466,15 @@ describe('TUI', function()
     end)
   end)
 
+  it('security: server-to-client API calls are rejected', function()
+    local ok, err = unpack(child_exec_lua([[
+      local ui = vim.api.nvim_list_uis()[1].chan
+      return { pcall(vim.rpcrequest, ui, 'nvim_exec_lua', 'return vim.fn.getpid()', {}) }
+    ]]))
+    eq(false, ok)
+    t.matches('UI client does not accept API calls: nvim_exec_lua', err)
+  end)
+
   it('stdin and stdout are tty fds in embedded server #38172', function()
     eq(
       { 'tty', 'tty' },